Thiamin pyrophosphate biochemistry
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Thiamin pyrophosphate biochemistry

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Published by CRC Press in Boca Raton, Fla .
Written in English


  • Vitamin B1 -- Congresses.,
  • Thiamin pyrophosphate -- Congresses.,
  • Thiamine -- congresses.,
  • Thiamine Pyrophosphate -- congresses.

Book details:

Edition Notes

Statementeditors, Alfred Schellenberger and Richard L. Schowen.
ContributionsSchellenberger, Alfred., Schowen, Richard L., Martin-Luther-Universität Halle-Wittenberg., Biochemische Gesellschaft der Deutschen Demokratischen Republik.
LC ClassificationsQP772.T5 T48 1988
The Physical Object
Pagination2 v. :
ID Numbers
Open LibraryOL2381701M
ISBN 100849346819, 0849346827, 0849346835
LC Control Number87010367

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Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the most important being the coenzyme thiamine diphosphate (ThDP). The important part of the thiamine molecule is the thiazole ring (look again at the structure of thiamine diphosphate on the previous page), thus we will draw thiamine (and later, thiamine diphosphate) using R groups to depict the unreactive parts of the molecule. The first step of the benzoin condensation is deprotonation of thiamine by hydroxide. Thiamine-PP. B-Neurox. Thiaminediphosphate. Thiaminpyrophosphate. TPP (coenzyme) Thiaminepyrophosphate. Co-Bi. Cocarboxylase chloride. TDP (thiamin ester) UNII-XMK8K8EVIU. Cocarboxylasum [INN-Latin] Thiamine pyrophosphoric ester. Cocarboxilasa [INN-Spanish] Cocarboxylase [INN:DCF:JAN] Co-carboxylase [BAN] XMK8K8EVIU. EINECS thiamine.   Thiamine pyrophosphate (TPP) is a thiamine (vitamin B1) derivative produced by the enzyme thiamine pyrophosphotase. As a coenzyme, it is present in all living systems and is important for catalyzing several biochemical reactions. It was first discovered while studying the peripheral nervous system disease Beriberi, which results from a.

Thiamine thiazolone pyrophosphate is a transition-state analog. The sulfur-containing ring of this analog is uncharged, and so it closely resembles the transition state of the normal coenzyme in thiamine-catalyzed reactions (e.g., the uncharged resonance form of hydroxyethyl-TPP) Nutrients are chemical substances required by the body to sustain basic functions and are optimally obtained by eating a balanced diet. There are six major classes of nutrients essential for human health: carbohydrates, lipids, proteins, vitamins, minerals, and water. Carbohydrates, lipids, and proteins are considered macronutrients and serve as a source of energy. Thiamine pyrophosphate: helps with tissue respiration. Coenzyme A transports acetyl groups from one substrate to another subtrate. For more information on Cofactors, see Cofactor (biochemistry). References. 1. Anderson, J. and L. Young. "Fat-Soluble Vitamins." Food and Nutrition Series. Thiamine occurs in the human body as free thiamine and as various phosphorylated forms: thiamine monophosphate, thia-mine triphosphate, and thiamine pyrophosphate, which is also known as thiamine diphosphate. The hydroxyl group of thia-mine in thiamine pyrophosphate is replaced by a diphosphate ester group (Figure 2).

This is due to a decreased rate of the reaction, pyruvic acid àacetyl-S—CoA, which needs thiamine pyrophosphate as a coenzyme. The ratio, blood lactic acid; blood pyruvic acid is also abnormally increased. Factors Affecting Requirements of Vitamin B1 (Thiamine) The requirements of thiamine are increased in the following conditions. Summary Thiamine (Vitamin B1) is a water-soluble vitamin and an important constituent of TPP (thiamine pyrophosphate), a cofactor found in several important dehydrogenase reactions. Specifically, TPP is an important cofactor for pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and branched-chain ketoacid dehydrogenase. Besides dehydrogenase reactions, TPP also serves an .   The alcohol group of thiamine is esterfied with phosphate (2 moles) to form the coenzyme, thiamine pyrophosphate (TPP or Cocarboxylase) The phosphate moiety is donated by ATP & reaction is catalyzed by thiamine pyrophosphate transferase Thiamine is a sulphur containing water soluble vitamin 4.   Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the α-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids. So far, HACL1 is the only known peroxisomal TPP-dependent enzyme in mammals. Little is known about the transport of metabolites and cofactors across the peroxisomal membrane and no peroxisomal thiamine.